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LDN s ability to block a key receptor (TLR 4) on microglial cells appears to inhibit them from becoming activated and is another good reason to try it in both FM and ME/CFS. Low Dose Naltrexone Philadelphia Development of IRT-103/Lodonal for Pediatric and Adult Crohn’s is currently in R&D to reach a Phase III US Trial.
It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain.
